The condition appears to have a genetic component and those effected often have both male and female relatives with adult-onset diabetes, obesity, elevated blood triglycerides, high blood pressure and female relatives with infertility, hirsutism and menstrual problems. Captopril is used alone or in combination with other medications to treat high blood pressure and heart failure. It is also used to improve survival and reduce the risk of heart failure after a heart attack in patients a heart condition called left ventricular hypertrophy (enlargement of the walls of the left side of the heart). Le valsartan (antagoniste des récepteurs de l'angiotensine II) peut être utilisé à la place du captopril (inhibiteur de l'enzyme de conversion, IEC) chez les patients avec un infarctus du myocarde (IDM) compliqué par une dysfonction ventriculaire gauche. It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation. Do not take captopril and hydrochlorothiazide if you are pregnant. If you become pregnant while taking captopril and hydrochlorothiazide, call your doctor immediately. Captopril is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II. Après un suivi médian d’un peu plus de deux ans, il apparaît que le risque de décès est le même dans les trois groupes. Toutefois, les effets secondaires indésirables étaient les plus nombreux avec l’association captopril et valsartan. Captopril Tablets, USP are available containing 12.5 mg, 25 mg, 50 mg or 100 mg of captopril, USP. The 12.5 mg tablets are white to off-white, oval, flat, beveled-edge tablets, debossed with S1 on one side and partial bisected on both sides. Interpretation of captopril renography by nuclear medicine physicians. Schreij G(1), van Kroonenburgh MJ, Heidendal GK, van der Pol HA, de Leeuw PW. Author information: (1)Department of Internal Medicine, University Hospital, Maastricht, The Netherlands.